When Holly Summerhays, a young, new-to-the-city reporter for NY1, arrives at real estate heiress Dee Dee Hollingsworth's eastside condo to interview her as New Yorker of the Week for her work in introducing opera to youngsters, she is inducted into the socialite's circle of friends which includes soap opera vamp, Dana Reynolds and curmudgeonly, wisecracking author, Meg Lafferty. Their friendship solidifies as they teach Holly the ins and outs of New York City, despite some setbacks in their personal lives.
	Holly pursues an affair with a rising celebrity French chef and they become a New York power couple until illness and ambition split them apart. Dee Dee finally decides to end her 16-year marriage with her philandering husband. Dana is written out of her role as ‘Monica St. James’ in “Passion Cove”, only to resurface as a musical comedy star. And Meg overcomes her writer's block to produce a bestseller and finally find love.
Through all their tribulations, they learn that friendship is the one thing they can count on. In the end, they emerge stronger, wiser, and happier as they face the future. Men come and go but their sorority remains intact.